Capillary Electrophoresis

Capillary electrophoresis (CE) is a separation method of electro-kinetic which is used in performing in submillimeter diameter capillaries and in micro- nanofluidic channels. The techniques include capillary gel electrophoresis, capillary isoelectric focusing, capillary isotachophoresis and micellar electrokinetic chromatography. In these methods under the influence of an electric field and often separated according to ionic mobility or partitioning into an alternate phase through the non-covalent interactions. The main application of capillary electrophoresis in forensic science for amplification and detection of the DNA fragments using polymerase chain reaction which lead to rapid advances in DNA typing in forensic and DNA separations are carried out using thin CE.

Forensic sample the biologist is typing of STR from biological samples is to generate highly polymorphic genetic markers which differ between individuals. The detection of specific mRNA fragments to help identify the biological fluid or tissue. It is also used in ink analysis counterfeiting of documents. Micellar electrophoretic capillary chromatography (MECC) has been developed and applied to the analysis of inks containing several similar substances of chemicals and the inks used can also be distinguished.