Liquid chromatography-Mass spectrometry is a analytical chemistry process that mixes the physical separation capabilities of liquid action with the mass analysis capabilities of mass analysis. Liquid chromatography-Mass spectrometry  may be a powerful technique used for several applications that has terribly high sensitivity and property. Usually its application is destined towards the overall detection and potential identification of chemicals within the presence of alternative chemicals. LC-MS system is used for quick and mass directed purification of natural-products extracts and new molecular entities which are necessary to food, pharmaceuticalagrochemical and alternative industries.

Gas chromatography–mass spectrometry (GC-MS) is an analytical method that combines the features of gas-chromatography and mass spectrometry to identify different substances within a test sample. Applications of GC-MS include drug detection, fire investigation, environmental analysisexplosives investigation, and identification of unknown samples, including that of material samples obtained from planet Mars during probe missions as early as the 1970s. GC-MS can also be used in airport security to detect substances in luggage or on human beings. Additionally, it can identify trace elements in materials that were previously thought to have disintegrated beyond identification.