Mass Spectrometry

Biography

Master in organic chemistry from Université de Sherbrooke, he worked for more than 10 years in the pharmaceutical industry in Canada and the United States. For the last 8 years he has pursued his career at the Centre de Toxicologie du Québec (CTQ) where he is involved in the development of new and specialized analytical methods, to assess exposure to heavy metals, solvents and their metabolites, pesticides and other environmental pollutants.With the help of his colleagues at the CTQ he recently published a paper on the matrix effects subject.  

Abstract

The effects of the matrix on the analysis may have numerous impacts on the quantification of an analyte. This may lead to confusion on what is actually measure, due to a non-universal terminology used in the scientific literature. In the hope bringing more clarity to the MEs we introduced new terms, and showed the relationship between them. We design a series of experiments to visualise how well the MEs are controlled, and to gain knowledge of where the perceived variations are coming from. The links between the different MEs and descriptors are presented, providing a pathway to follow when doing troubleshooting work. The results obtained with the test provided information on both the analytes and the internal standards facilitating the analyte/internal standard association for a correct quantification in the sample matrices. The technique presented is applicable to matrices containing a base quantity of the analyte, and to different types of instruments like LC, GC and ICP. This methodology facilitates the decision-making process while lowering the required costs and time.